Intrinsic (Genotype) and Extrinsic (Environment) Factors in the Temporal Patterns of Nest-Building Process : Effect of Forced Isolation in Old Female Mice with Normal and AD-Pathological Aging
De Molina García, Ana Ruiz (Universitat Autònoma de Barcelona. Institut de Neurociències)
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal

Fecha:	2021
Descripción:	2 pàg.
Resumen:	The impact of isolation has become a critical worldwide issue since the outbreak of the COVID-19 pandemic. In nursing homes, the physical distance measures forced the separation of old patients in restricted areas and rooms to avoid the spread of the virus. Similarly, older people living at home face severe restrictions as the best preventive strategy to protect their lives before vaccination is possible/effective. At the translational level, we recently demonstrated the impact of isolation in male 3×Tg-AD mice for Alzheimer's disease and the increase in gross and fine motor activity. The latter was monitored through nesting, a species-typical ethological behavior used as a naturalistic approach to measuring animals' well-being and abilities in instrumental tasks. In the present work, we scored the nests and the nest-building process in old females under the effects of intrinsic (genotype, 3×Tg-AD vs. C57BL/6J) and extrinsic (environment, forced isolation vs. social environment) factors. Nests were scored according to the ordinal Deacon Scale, whereas the temporal progress of nest construction was determined with a new parametric (numeric) measurement analog. The results confirmed previously described genotype differences, with worse nests in 3×Tg-AD mice living under standard housing conditions than their non-transgenic counterparts, at 48 and 72 h. However, the genotype effect was lost under isolation, mainly due to isolated 3×Tg-AD females enhancing nest-building behavior, while isolated non-transgenic counterparts were less efficient at 24 h. The results also indicate that temporal patterns of the nest-building process are important to be considered when measuring the effects of intrinsic and extrinsic factors.
Ayudas:	European Commission. Horizon 2020 737390
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alzheimer's disease ; Aging ; Social isolation ; COVID-19 ; Executive functions ; Daily life activities ; Nesting
Publicado en:	Medical sciences forum, Vol. 8, Núm. 1 (July 2021) , ISSN 2673-9992

DOI: 10.3390/IECBS2021-10677

2 p, 220.3 KB

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