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Institut de Neurociències (INc)

En el año 2003 un grupo de biólogos moleculares, fisiólogos, neuropatólogos, histólogos, psicólogos, psicobiólogos y bioinformáticos que trabajan en la UAB creamos el INc con el objetivo estratégico de dejar atrás las disciplinas tradicionales, y abordar de manera multidisciplinaria y translacional cuestiones claves del cerebro en el siglo XXI como son la neurodegeneración, la neuroregeneración y las bases de la mente normal o trastornada. Nos interesa cómo funciona el cerebro normal, qué ocurre cuando enferma, y cómo se cura. Exploramos todos los niveles de la organización biológica desde la interacción de moléculas al comportamiento usando para ello cultivos celulares, modelos animales y pacientes. Nuestro objetivo final es desarrollar nuevas terapias celulares, moleculares, genéticas para el tratamiento de patologías cerebrales.

 
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2025-03-21
10:59
11 p, 1.5 MB The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in women with no trauma/low trauma / Velasco García, Eric Raúl (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fabregat Nabás, Jaime (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Torrents-Rodas, David (University of Hamburg) ; Arias, Barbara (Universitat de Barcelona) ; Torrúbia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Fullana, Miguel (Hospital Clínic i Provincial de Barcelona) ; Andero Galí, Raül (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Women are known to have twice as much lifetime prevalence of post-traumatic stress disorder (PTSD) as men do. It has been reported that the risk genotype (CC) of a single nucleotide polymorphism (SNP) (rs2267735) in the pituitary adenylate cyclase-activating polypeptide (PACAP-PAC1R) system is associated with PTSD risk and altered fear conditioning and fear extinction in women. [...]
2025 - 10.1016/j.biopsycho.2024.108981
Biological psychology, Vol. 194 (January 2025) , p. 108981  
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2025-02-20
10:27
13 p, 5.7 MB HEBE : A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease / Esandi Jauregui, Jon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Renault de Barros, Pedro Victor (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Capilla López, Maria Dolores (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Blanch, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Edo Salvador, Ángel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramirez-Gómez, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bosch i Merino, Assumpció (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Saura, Carlos Alberto (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública) ; Chillón Rodríguez, Miguel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-β and Tau protein depositions, with treatments focusing on single proteins have shown limited success due to the complexity of pathways involved. [...]
2025 - 10.1016/j.biopha.2025.117815
Biomedicine & pharmacotherapy, Vol. 183 (February 2025)  
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2025-02-19
10:45
2 p, 207.8 KB Obesity, Impaired Glucose Metabolism and Hepatic Histopathological Damage in 3xTg-AD Mice at Different Stages of Disease Compared to Mice with Normal Aging / Pérez-Gozalbo, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
The crosstalk between obesity, diabetes, steatohepatitis, and dementia creates a controversial scenario when also studied using animal models. In the present work, this crosstalk was investigated in male and female 3xTg-AD mice for Alzheimer's disease (AD) at different ages/stages and compared to sex- and age-matched counterparts with normal aging. [...]
2022 - 10.3390/IECBS2022-12938
Biology and life sciences forum, Vol. 19, Núm. 1 (September 2022)  
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2025-02-19
10:45
2 p, 201.4 KB Reference Models for Children and Young People with Epidermolysis Bullosa : First Case Report on the Protective Factors and Challenges for Psycho-Social Maturation and Resilience / Salas-Llopart, Mar (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Epidermolysis Bullosa (EB) is a chronic disease with multiple clinical presentations, depending on the subtype. It is characterized by the structural fragility of skin and tissues which results in lesions. [...]
2022 - 10.3390/IECBS2022-12948
Biology and life sciences forum, Vol. 19, Núm. 1 (September 2022) , p. 11  
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2025-02-19
10:45
2 p, 217.0 KB Sex-Dependent Hepatomegaly, and Increased Hepatic Oxidative Stress in Old Male and Female 3xTg-AD Mice as Compared to Mice with Physiological Aging / Fraile-Ramos, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
When it comes to neurodegenerative disorders, Alzheimer's disease (AD) is one of the main causes of dementia in older people. Until now, studies have focused on alterations occurring in the brain. However, it has been shown that along with the accumulation of beta-amyloid plaques and tau proteins, oxidative stress and inflammation also play a role in this disease's pathophysiology. [...]
2021 - 10.3390/IECBS2021-10668
Medical sciences forum, Vol. 8, Núm. 1 (2021)  
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2025-02-19
10:45
18 p, 1.6 MB Parochial Linguistic Education : Patterns of an Enduring Friction within a Divided Catalonia / Oller i Sala, Josep Maria (Universitat de Barcelona) ; Satorra, Albert (Universitat Pompeu Fabra) ; Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Amid the tensions created by the secession push in Catalonia (Spain), an important conflicting issue has been the "immersion linguistic educational system", in which the Catalan language has precedence throughout all of the primary and secondary school curricula. [...]
2021 - 10.3390/genealogy5030077
Genealogy, Vol. 5, Núm. 3 (2021)  
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2025-02-19
10:45
6 p, 241.6 KB Immigration and Logotherapy : Addressing Mental Health Problems among Muslim Immigrants in Europe / Rahgozar, Shirin (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Depression, stress, anxiety disorders, and PTSD are some of the mental health problems that are prevalent among immigrant populations despite being underdiagnosed. Stigma, difficulties in adapting, cultural barriers, and reduced access to mental health support can seriously hamper their ability to build resilience and recover. [...]
2022 - 10.3390/IECBS2022-12937
Biology and life sciences forum, Vol. 19, Núm. 1 (September 2022)  
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2025-02-19
10:45
3 p, 226.1 KB Sex-Dependent Variations in Voluntary Exercise of 14-Month-Old 3xTg-AD Mice Associated with Novelty Inhibition / Alveal-Mellado, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Alzheimer's Disease (AD) patients suffer from circadian rhythm alterations involving sleep, thermoregulation, and movement activity disorders. The latter affects their daily patterns of physical activity (PA) and willingness to perform voluntary exercise, impeding benefit from routine PA practice. [...]
2022 - 10.3390/IECBS2022-12946
Biology and life sciences forum, Vol. 19, Núm. 1 (September 2022)  
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2025-02-19
10:45
2 p, 220.3 KB Intrinsic (Genotype) and Extrinsic (Environment) Factors in the Temporal Patterns of Nest-Building Process : Effect of Forced Isolation in Old Female Mice with Normal and AD-Pathological Aging / De Molina García, Ana Ruiz (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
The impact of isolation has become a critical worldwide issue since the outbreak of the COVID-19 pandemic. In nursing homes, the physical distance measures forced the separation of old patients in restricted areas and rooms to avoid the spread of the virus. [...]
2021 - 10.3390/IECBS2021-10677
Medical sciences forum, Vol. 8, Núm. 1 (July 2021)  
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2025-02-19
10:45
2 p, 201.9 KB Reference Models for Children and Young People with Epidermolysis Bullosa : First Case Report on the Challenges, Rewards, and Limiting Factors for Successful Academic and Professional Achievements / Shin Kang, Ju Young (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Epidermolysis bullosa (EB), also known as Butterfly skin, is a term for a heterogeneous group of rare genodermatosis disorders resulting in painful mucocutaneous blisters and extreme fragility with minor trauma or friction. [...]
2022 - 10.3390/IECBS2022-12939
Biology and life sciences forum, Vol. 19, Núm. 1 (September 2022)  
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